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11 results in Keywords: Covalent inhibitor

Biological and Medicinal Chemistry

Working Paper

Targeted Covalent Inhibition of Telomerase

Rick Betori, Yue Liu, Ding Wu, Rama Mishra, Scott Cohen, Stephen J. Kron, Karl Scheidt

Version 1 posted 23 July 2019

898

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Biological and Medicinal Chemistry

Working Paper

Structure–activity Relationships of Glutathione Peroxidase 4 Inhibitor Warheads

John Eaton, Laura Furst, Luke Cai, Vasanthi S. Viswanathan, Stuart L. Schreiber

Version 1 posted 20 April 2020

848

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Biological and Medicinal Chemistry

Working Paper

Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2

Sarath Ramachandran, Nikolai Makukhin, Kevin Haubrich, Manjula Nagala, Beth Forrester, Dylan Lynch, Ryan Casement, Andrea Testa, Elvira Bruno, Rosaria Gitto, Alessio Ciulli

Version 2 posted 16 August 2023

2,404

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Biological and Medicinal Chemistry

Working Paper

α-Methylene-β-Lactone Probe for Measuring Live-Cell Reactions of Small Molecules

Lei Wang, Louis Riel, Bekim Bajrami, Bin Deng, Amy Howell, Xudong Yao

Version 2 posted 13 April 2020

795

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Organic Chemistry

Working Paper

Diversity Oriented Clicking: Synthesis of beta-Substituted Alkenyl Sulfonyl Fluorides as Covalent Human Neutrophil Elastase Inhibitors

Yunfei Cheng, Gencheng Li, Christopher J. Smedley, Marie-Claire Giel, Seiya Kitamura, Jordan L. Woehl, Giulia Bianco, Stefano Forli, Joshua A. Homer, John R. Cappiello, Dennis W. Wolan, John E. Moses, K. Barry Sharpless

Version 1 posted 25 April 2022

605

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Biological and Medicinal Chemistry

Working Paper

Pitfalls and considerations in determining the potency and mutant selectivity of covalent epidermal growth factor receptor inhibitors

Kristopher W Hoyt, Daniel A Urul, Blessing C Ogboo, Florian Wittlinger, Stefan A Laufer, Erik M Schaefer, Earl W May, David E Heppner

Version 1 posted 24 August 2023

271

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Biological and Medicinal Chemistry

Working Paper

Fluoromethylketone-fragment conjugates designed as covalent modifiers of EcDsbA are atypical substrates

Bradley Doak, Rebecca Whitehouse, Kieran Rimmer, Martin Williams, Begona Heras, Sofia Caria, Olga Ilyichova, Mansha Vazirani, Biswaranjan Mohanty, Jason Harper, Martin Scanlon, Jamie Simpson

Version 1 posted 17 February 2022

285

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Citations

Biological and Medicinal Chemistry

Working Paper

Covalent Bonding Aptamer with Enhanced SARS-CoV-2 RBD-ACE2 Blocking and Pseudovirus Neutralization Activities

Zichen Qin, Yiying Zhu, Yu Xiang

Version 2 posted 28 December 2021

1,708

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Citations

Biological and Medicinal Chemistry

Working Paper

“Sleeping Beauty” Phenomenon: SuFEx-Enabled Discovery of Selective Covalent Inhibitors of Human Neutrophil Elastase

Qinheng Zheng, Jordan L. Woehl, Seiya Kitamura, Diogo Santos-Martins, Christopher J. Smedley, Gencheng Li, Stefano Forli, John E. Moses, Dennis W. Wolan, K. Barry Sharpless

Version 1 posted 15 March 2019

1,592

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Citations

Biological and Medicinal Chemistry

Working Paper

Diacylfuroxans Are Masked Nitrile Oxides That Inhibit GPX4 Covalently

John Eaton, Richard A. Ruberto, Anneke Kramm, Vasanthi S. Viswanathan, Stuart Schreiber

Version 1 posted 23 January 2019

828

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11 results in Covalent inhibitor in Keywords: Covalent inhibitor

Targeted Covalent Inhibition of Telomerase

Structure–activity Relationships of Glutathione Peroxidase 4 Inhibitor Warheads

Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2

α-Methylene-β-Lactone Probe for Measuring Live-Cell Reactions of Small Molecules

Diversity Oriented Clicking: Synthesis of beta-Substituted Alkenyl Sulfonyl Fluorides as Covalent Human Neutrophil Elastase Inhibitors

Pitfalls and considerations in determining the potency and mutant selectivity of covalent epidermal growth factor receptor inhibitors

Fluoromethylketone-fragment conjugates designed as covalent modifiers of EcDsbA are atypical substrates

Covalent Bonding Aptamer with Enhanced SARS-CoV-2 RBD-ACE2 Blocking and Pseudovirus Neutralization Activities

“Sleeping Beauty” Phenomenon: SuFEx-Enabled Discovery of Selective Covalent Inhibitors of Human Neutrophil Elastase

Diacylfuroxans Are Masked Nitrile Oxides That Inhibit GPX4 Covalently

11 results in Keywords: Covalent inhibitor