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Identification and benchmarking of Myokinasib-II as a highly selective and potent chemical probe for exploring MLCK1 inhibition

Gautam Kumar, Prema Kumari Agarwala, Aswin T. Srivatsav, Ashok Ravula, G. Ashmitha, Sreenath Balakrishnan, Shobhna Kapoor, Rishikesh Narayan

Version 1 posted 09 May 2024

139

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Organic Chemistry

Working Paper

SGC-CK2-1: The First Selective Chemical Probe for the Pleiotropic Kinase CK2

Carrow Wells, David Drewry, Julie E. Pickett, Alison D. Axtman

Version 2 posted 18 May 2020

917

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1

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Biological and Medicinal Chemistry

Working Paper

A Chemical Probe For Tudor Domain Protein Spindlin1 to Investigate Chromatin Functions

Vincent Fagan, Catrine Johansson, Carina Gileadi, Octovia P. Monteiro, James E. Dunford, Reshma Nibhani, Martin Philpott, Jessica Malzahn, Graham Wells, Ruth Farham, Adam Cribbs, Nadia Halidi, Fengling Li, Irene Chau, Holger Greschik, Srikannathasan Velupillai, Abdellalh Allali- Hassani, James Bennett, Thomas Christott, Charline Giroud, Andrew M Lewis, Kilian Huber, Nick Athanasou, Chas Bountra, Manfred Jung, Roland Schüle, Masoud Vedadi, Cheryl Arrowsmith, Yan Xiong, Jian Jin, Oleg Fedorov, Gillian Farnie, Paul Brennan, Udo Oppermann

Version 2 posted 30 May 2019

1,097

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1

Citations

Biological and Medicinal Chemistry

Working Paper

Potent and Selective N-Terminal BRD4 Bromodomain Inhibitors by Targeting Non-Conserved Residues and Structured Water Displacement

Huarui Cui, Anand Divakaran, Anil K. Pandey, Jorden A. Johnson, huda zahid, zachary hoell, mikael ellingson, ke shi, Hideki Aihara, Daniel A. Harki, william pomerantz

Version 1 posted 23 April 2020

565

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Biological and Medicinal Chemistry

Working Paper

1-(Aminomethyl)-Trans-Cyclooct-4-Ene, a New TCO Derivative for Target Visualization and Target Engagement Measurement in Cells

Cécile Echalier, Anna Rutkowska, Douglas W. Thomson, Lee Edwards, Blandine McKay, Marcel Muelbaier, Carsten Schultz, Giovanna Bergamini

Version 1 posted 03 November 2020

312

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Biological and Medicinal Chemistry

Working Paper

Autoinducer-Fluorophore Conjugates Enable FRET in LuxR Proteins in Vitro and in Cells

Matthew Styles, Michelle Boursier, Margaret McEwan, Emma Santa, Margrith Mattmann, Betty Slinger, Helen Blackwell

Version 1 posted 17 February 2022

267

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Biological and Medicinal Chemistry

Working Paper

Improved Electrophile Design for Exquisite Covalent Molecule Selectivity

José Montaño, Brian Wang, Regan Volk, Virginia Garda, Balyn Zaro

Version 2 posted 16 November 2021

1,131

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Biological and Medicinal Chemistry

Working Paper

Discovery of a Potent and Selective Naphthyridine-based Chemical Probe for Casein Kinase 2

Zachary W. Davis-Gilbert, Andreas Krämer, James E. Dunford, Stefanie Howell, Filiz Senbabaoglu, Carrow I. Wells, Tammy M. Havener, Jeffery L. Smith, Mohammad A. Hossain, Udo Oppermann, David H. Drewry, Alison D. Axtman

Version 1 posted 21 December 2022

169

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Biological and Medicinal Chemistry

Working Paper

A Visible Light-triggered Ferroptosis Probe: Visualization, Endoplasmic Reticulum Localization and Photo-induced Lipid Peroxidation

Zhibin Song, Zhiming Xing, Jiangyu Yan, Yongxiang Miao, Yawen Ruan, Youkang Zhou, Yingqun Tang, Guorui Li, Jing Huang, Yiyuan Peng

Version 1 posted 21 July 2021

404

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Biological and Medicinal Chemistry

Working Paper

Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses

David H. Drewry, Frances M. Potjewyd, Jeffrey L. Smith, Rebekah J. Dickmander, Armin Bayati, Stefanie Howell, Sharon A. Taft-Benz, Mohammad Anwar Hossain, Mark T. Heise, Peter S. McPherson, Nathaniel J. Moorman, Alison D. Axtman

Version 1 posted 27 April 2022

221

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16 results in Chemical probe in Keywords: Chemical probe

Identification and benchmarking of Myokinasib-II as a highly selective and potent chemical probe for exploring MLCK1 inhibition

SGC-CK2-1: The First Selective Chemical Probe for the Pleiotropic Kinase CK2

A Chemical Probe For Tudor Domain Protein Spindlin1 to Investigate Chromatin Functions

Potent and Selective N-Terminal BRD4 Bromodomain Inhibitors by Targeting Non-Conserved Residues and Structured Water Displacement

1-(Aminomethyl)-Trans-Cyclooct-4-Ene, a New TCO Derivative for Target Visualization and Target Engagement Measurement in Cells

Autoinducer-Fluorophore Conjugates Enable FRET in LuxR Proteins in Vitro and in Cells

Improved Electrophile Design for Exquisite Covalent Molecule Selectivity

Discovery of a Potent and Selective Naphthyridine-based Chemical Probe for Casein Kinase 2

A Visible Light-triggered Ferroptosis Probe: Visualization, Endoplasmic Reticulum Localization and Photo-induced Lipid Peroxidation

Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses

16 results in Keywords: Chemical probe