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PROTAC degraders of the METTL3-14 m6A-RNA methyltransferase

Francesco Errani, Annalisa Invernizzi, Marcin Herok, Elena Bochenkova, Fiona Stamm, Ivan Corbeski, Valeria Romanucci, Giovanni Di Fabio, František Zálešák, Amedeo Caflisch

Version 2 posted 06 February 2024

723

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Analytical Chemistry

Working Paper

Proximity Biosensor Assay for PROTAC Ternary Complex Analysis

Irene Ponzo, Alice Solda, Charlotte Crowe, Goran Dahl, Stefan Geschwindner, Alessio Ciulli, Ulrich Rant

Version 1 posted 06 March 2024

1,913

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Organic Chemistry

Working Paper

One-pot synthesis of CRBN PROTACs via photoinduced C(sp2)–C(sp3) cross coupling and amide formation for PROTAC library synthesis

Christine Marie Arndt, Jacqueline Bitai, Jessica Brunner, Till Opatz, Paola Martinelli, Andreas Gollner, Kevin R Sokol, Matthias Krumb

Version 1 posted 03 July 2023

2,293

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Biological and Medicinal Chemistry

Review

Rational Design of Molecular Glues: Breakthroughs and Perspectives

Juzeng An, Xiaojun Zhang

Version 2 posted 02 January 2024

1,070

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Biological and Medicinal Chemistry

Working Paper

Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs

Christian Steinebach, Izidor Sosič, Aleša Bricelj, Arunima Murgai, Luca Bischof, Yuen Lam Dora Ng, Christopher Heim, Samuel Maiwald, Matic Proj, Rabea Voget, Felix Feller, Janez Košmrlj, Annika Schmidt, Patricia Lemnitzer, Finn K. Hansen, Michael Gütschow, Jan Krönke, Marcus D. Hartmann

Version 1 posted 21 April 2023

1,597

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1

Citations

Biological and Medicinal Chemistry

Working Paper

Linker-dependent folding rationalizes PROTAC cell permeability

Vasanthanathan Poongavanam, Yoseph Atilaw, Stephan Siegel, Anja Giese, Lutz Lehmann, Daniel Meibom, Mate Erdelyi, Jan Kihlberg

Version 1 posted 04 May 2022

3,841

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Theoretical and Computational Chemistry

Working Paper

In Silico Modeling and Scoring of PROTAC-Mediated Ternary Complex Poses

Junzhuo Liao, Xueqing Nie, Ilona Unarta, Spencer Ericksen, Weiping Tang

Version 3 posted 20 December 2021

2,035

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Biological and Medicinal Chemistry

Working Paper

Leveraging dual-ligase recruitment to enhance degradation via a heterotrivalent PROTAC

Adam G. Bond, Miquel Muñoz i Ordoño, Celia M. Bisbach, Conner Craigon, Nikolai Makukhin, Elizabeth A. Caine, Manjula Nagala, Marjeta Urh, Georg E. Winter, Kristin M. Riching, Alessio Ciulli

Version 1 posted 21 August 2024

2,089

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8 results in CRBN in Keywords: CRBN

PROTAC degraders of the METTL3-14 m6A-RNA methyltransferase

Proximity Biosensor Assay for PROTAC Ternary Complex Analysis

One-pot synthesis of CRBN PROTACs via photoinduced C(sp2)–C(sp3) cross coupling and amide formation for PROTAC library synthesis

Rational Design of Molecular Glues: Breakthroughs and Perspectives

Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs

Linker-dependent folding rationalizes PROTAC cell permeability

In Silico Modeling and Scoring of PROTAC-Mediated Ternary Complex Poses

Leveraging dual-ligase recruitment to enhance degradation via a heterotrivalent PROTAC

8 results in Keywords: CRBN