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Structural optimization of oxaprozin for selective inverse Nurr1 agonism

Sabine Willems, Romy Busch, Felix Nawa, Marco Ballarotto, Felix F. Lillich, Till Kasch, Úrsula López-García, Julian A. Marschner, Lorena A. Rüger, Beatrice Renelt, Julia Ohrndorf, Silvia Arifi, Daniel Zaienne, Ewgenij Proschak, Jörg Pabel, Daniel Merk

Version 1 posted 30 July 2024

99

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Organic Chemistry

Working Paper

Contilisant+Belinostat hybrids, as new multi-target-directed polyfunctionalized indole derivatives able to inhibit histone deacetylase/cholinesterase/monoamine oxidase enzymes, and modulate histamine 3/sigma 1/5-HT6/dopamine 3 receptors for the treatment of cancer and neurodegenerative diseases

Mireia Toledano-Pinedo, Alicia Porro, Saray Macaulet, Pedro Almendros, Isabel Iriepa, M. Mercedes Rodríguez-Fernández, Francisco López-Muñoz, Aizpea Artetxe-Zurutuza, Ander Matheu, José Marco-Contelles

Version 1 posted 03 August 2023

216

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Biological and Medicinal Chemistry

Review

Alzheimer's Disease: Exploring the Landscape of Cognitive Decline

Rumiana Tenchov, Janet Sasso, Qiongqiong Angela Zhou

Version 2 posted 03 June 2024

292

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Biological and Medicinal Chemistry

Working Paper

Successful Design of a Multivalent Bifunctional Chelator for Diagnostic 64Cu PET Imaging in Alzheimer’s Disease

Hong-Jun Cho, Truc T. Huynh, Buck E. Rogers, Liviu M. Mirica

Version 1 posted 05 June 2020

403

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Inorganic Chemistry

Working Paper

Benzothiazole Carboxylate Diester Bifunctional Chelators for 64Cu PET Imaging in Alzheimer’s Disease

Yujue Wang, Truc T. Huynh, Nilantha Bandara, Hong-Jun Cho, Buck E. Rogers, Liviu M. Mirica

Version 1 posted 11 May 2021

231

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Biological and Medicinal Chemistry

Working Paper

Amentoflavone: A Bifunctional Metal Chelator that Controls the Formation of Neurotoxic Soluble Aβ42 Oligomers

Liang Sun, Anuj K. Sharma, Byung-Hee Han, Liviu M. Mirica

Version 1 posted 09 June 2020

377

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Biological and Medicinal Chemistry

Working Paper

A Multifunctional Chemical Agent as an Attenuator of Amyloid and Tau Burden and Neuroinflammation in Alzheimer’s Disease

Hong-Jun Cho, Anuj K. Sharma, Ying Zhang, Michael L. Gross, Liviu M. Mirica

Version 1 posted 23 December 2019

497

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Biological and Medicinal Chemistry

Working Paper

Amphiphilic Stilbene Derivatives Attenuate the Neurotoxicity of Soluble Aβ42 Oligomers by Controlling Their Interactions with Cell Membranes

Liviu M. Mirica

Version 2 posted 22 August 2022

395

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Analytical Chemistry

Working Paper

Rapid, Refined, and Robust Method for Expression, Purification, and Characterization of Recombinant Human Amyloid-beta M1-42

Priya Prakash, Travis Lantz, Krupal P. Jethava, Gaurav Chopra

Version 1 posted 15 February 2019

537

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Biological and Medicinal Chemistry

Working Paper

Structural Impact of Pyroglutamylation at Glu3 in an Amyloid-β(3-42) Fibril Probed by Solid-State NMR Spectroscopy

Luis Gardon, Nina Becker, Lothar Gremer, Henrike Heise

Version 1 posted 08 June 2023

134

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Refine Search

20 results in Alzheimer’s Disease in Keywords: Alzheimer’s Disease

Structural optimization of oxaprozin for selective inverse Nurr1 agonism

Contilisant+Belinostat hybrids, as new multi-target-directed polyfunctionalized indole derivatives able to inhibit histone deacetylase/cholinesterase/monoamine oxidase enzymes, and modulate histamine 3/sigma 1/5-HT6/dopamine 3 receptors for the treatment of cancer and neurodegenerative diseases

Alzheimer's Disease: Exploring the Landscape of Cognitive Decline

Successful Design of a Multivalent Bifunctional Chelator for Diagnostic 64Cu PET Imaging in Alzheimer’s Disease

Benzothiazole Carboxylate Diester Bifunctional Chelators for 64Cu PET Imaging in Alzheimer’s Disease

Amentoflavone: A Bifunctional Metal Chelator that Controls the Formation of Neurotoxic Soluble Aβ42 Oligomers

A Multifunctional Chemical Agent as an Attenuator of Amyloid and Tau Burden and Neuroinflammation in Alzheimer’s Disease

Amphiphilic Stilbene Derivatives Attenuate the Neurotoxicity of Soluble Aβ42 Oligomers by Controlling Their Interactions with Cell Membranes

Rapid, Refined, and Robust Method for Expression, Purification, and Characterization of Recombinant Human Amyloid-beta M1-42

Structural Impact of Pyroglutamylation at Glu3 in an Amyloid-β(3-42) Fibril Probed by Solid-State NMR Spectroscopy

20 results in Keywords: Alzheimer’s Disease