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Biological and Medicinal Chemistry

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Ryan Casement

2 results in Authors: Ryan Casement

Biological and Medicinal Chemistry

Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2

Sarath Ramachandran, Nikolai Makukhin, Kevin Haubrich, Manjula Nagala, Beth Forrester, Dylan Lynch, Ryan Casement, Andrea Testa, Elvira Bruno, Rosaria Gitto, Alessio Ciulli

Version 2 posted 16 August 2023

2,576

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Biological and Medicinal Chemistry

Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1alpha (HIF-1alpha) Stabilizers

Lan Phuong Vu, Claudia Diehl, Ryan Casement, Adam Bond, Christian Steinebach, Nika Strasek, Alesa Bricelj, Andrej Perdih, Gregor Schnakenburg, Izidor Sosic, Alessio Ciulli, Michael Gutschow

Version 2 posted 01 August 2023

1,327

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