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Philip C. Biggin

2 results in Authors: Philip C. Biggin

Biological and Medicinal Chemistry

Efficient large-scale exploration of fragment hit progression by exploiting binding-site purification of actives (B-SPA) through combining multi-step array synthesis and HT crystallography.

Harold Grosjean, Anthony Aimon, Storm Hassell-Hart, Warren Thompson, Lizbé Koekemoer, James Bennett, Cameron Anderson, Conor Wild, William Bradshaw, Edward A FitzGerald, Tobias Krojer, Anthony Bradley, Oleg Fedorov, Philip C. Biggin, John Spencer, Frank von Delft

Version 2 posted 09 February 2024

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Biological and Medicinal Chemistry

Structure-Activity-Relationships can be directly extracted from high-throughput crystallographic evaluation of fragment elaborations in crude reaction mixtures

Harold Grosjean, Kate Fieseler, Ruben Sanchez-Garcia, Warren Thompson, Charlotte M. Deane, Frank von Delft, Philip C. Biggin

Version 1 posted 28 May 2025

52

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