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From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9

Whitney L. Petrilli, Gregory Adam, Roman S. Erdmann, Pravien Abeywickrema, Viju Agnani, Xi Ai, Jen Baysarowich, Noel Byrne, John Caldwell, Wonsuk Chang, Edward DiNunzio, Zhe Feng, Rachel Ford, Sookhee Ha, Yongcheng Huang, Brian Hubbard, Jennifer M. Johnston, Michael Kavana, Jean-Marie Lisnock, Rui Liang, Jun Lu, Zhijian Lu, Juncai Meng, Peter Orth, Oksana Palyha, Gopal Parthasarathy, Scott P. Salowe, Sujata Sharma, Jennifer Shipman, Stephen Soisson, Alison Strack, Hyewon Youm, Kake Zhao, Debbie Zinc, Hratch Zokian, George Addona, Karen Akinsanya, James R. Tata, Yusheng Xiong, Jason E. Imbriglio

Version 1 posted 09 July 2019

1,058

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Analytical Chemistry

Working Paper

OptiMS: An Accessible Program for Automating Mass Spectrometry Parameter Optimization and Configuration

Peter J. H. Williams, Ian C. Chagunda, J. Scott McIndoe

Version 1 posted 21 September 2023

186

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Catalysis

Working Paper

Continuous Addition Kinetic Elucidation: Catalyst and Reactant Order, Rate Constant, and Poisoning from a Single Experiment

Peter Williams, Charles Killeen, Ian Chagunda, Brett Henderson, Sofia Donnecke, Wil Munro, Jaspreet Sidhu, Denaisha Kraft, David Harrington, Scott McIndoe

Version 2 posted 13 June 2022

1,413

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Inorganic Chemistry

Working Paper

How soft is your ESI-MS anyway?

Ian C. Chagunda, Peter J. H. Williams, Tiago Fisher, Naomi L. Stock, Daniel G. Beach, Gilian T. Thomas, Jane Zhu, J. Scott McIndoe

Version 1 posted 30 January 2024

167

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Biological and Medicinal Chemistry

Working Paper

DNAzymes for Amine and Peptide Lysine Acylation

Tianjiong Yao, Jack Przybyla, Peter Yeh, Austin Woodard, Hannah Nilsson, Benjamin Brandsen, Scott Silverman

Version 1 posted 28 September 2020

386

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Materials Chemistry

Working Paper

ARC-MOF: A Diverse Database of Metal-Organic Frameworks with DFT-Derived Partial Atomic Charges and Descriptors for Machine Learning

Jake Burner, Jun Luo, Andrew White, Adam Mirmiran, Ohmin Kwon, Peter G. Boyd, Stephen Maley, Marco Gibaldi, Scott Simrod, Victoria Ogden, Tom K. Woo

Version 1 posted 01 August 2022

1,506

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Organic Chemistry

Working Paper

Overcoming Limitations in Decarboxylative Arylation via Ag-Ni Electrocatalysis

Maximilian Palkowitz, Gabriele Laudadio, Simon Kolb, Jin Choi, Martins Oderinde, Tamara Ewing, Philippe Bolduc, TeYu Chen, Hao Zhang, Peter Cheng, Benxiang Zhang, Michael Mandler, Jeremy Richter, Michael Collins, Ryan Schioldager, Murali Dhar, Benjamin Vokits, Yeheng Zhu, Pierre-Georges Echeverria, Michael Poss, Scott Shaw, Sebastian Clementson, Nadia Petersen, Pavel Mykhailiuk, Phil Baran

Version 1 posted 27 May 2022

3,269

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3

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Biological and Medicinal Chemistry

Working Paper

Drugit: Crowd-sourcing molecular design of non-peptidic VHL binders

Thomas Scott, Christian Alan Paul Smethurst, Yvonne Westermaier, Moriz Mayer, Peter Greb, Roland Kousek, Tobias Biberger, Gerd Bader, Zuzana Jandova, Philipp S. Schmalhorst, Julian E. Fuchs, Aniket Magarkar, Christoph Hoenke, Thomas Gerstberger, Steven A. Combs, Richard Pape, Saksham Phul, Sandeepkumar Kothiwale, Andreas Bergner, Alex G. Waterson, Foldit Players, Harald Weinstabl, Darryl B. McConnell, Jark Böttcher, Jens Meiler, Rocco Moretti

Version 1 posted 11 May 2023

912

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Biological and Medicinal Chemistry

Working Paper

New insights from old data - Hunting for compounds with novel mechanisms using cellular high-throughput screening profiles with Grey Chemical Matter

Jason R Thomas, Claude Shelton IV, Jason Murphy, Scott Brittain, Mark-Anthony Bray, Peter Aspesi, John Concannon, Frederick J King, Robert J Ihry, Daniel J Ho, Martin Henault, Andrea Hadjikyriacou, Marilisa Neri, Frederic D Sigoillot, Helen T Pham, Matthew Shum, Louise Barys, Michael D Jones, Eric J Martin, Anke Blechschmidt, Sébastien Rieffel, Thomas J Troxler, Felipa A Mapa, Jeremy L Jenkins, Rishi K Jain, Peter S Kutchukian, Markus Schirle, Steffen Renner

Version 2 posted 20 October 2023

337

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Organic Chemistry

Working Paper

Organosilicon Precursors for Efficient Aromatic Copper-Mediated Radiocyanation

Jay Wright, Richard Ma, Casey McCarthy, Gina Kaup, Emma George, Joshua Duncan Priest, E. William Webb, Kevin Cheng, Gregory Bowden, Allen Brooks, Xia Shao, Melanie Sanford, Peter Scott

Version 1 posted 26 June 2024

158

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Refine Search

13 results in Peter Scott in Authors: Peter Scott

From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9

OptiMS: An Accessible Program for Automating Mass Spectrometry Parameter Optimization and Configuration

Continuous Addition Kinetic Elucidation: Catalyst and Reactant Order, Rate Constant, and Poisoning from a Single Experiment

How soft is your ESI-MS anyway?

DNAzymes for Amine and Peptide Lysine Acylation

ARC-MOF: A Diverse Database of Metal-Organic Frameworks with DFT-Derived Partial Atomic Charges and Descriptors for Machine Learning

Overcoming Limitations in Decarboxylative Arylation via Ag-Ni Electrocatalysis

Drugit: Crowd-sourcing molecular design of non-peptidic VHL binders

New insights from old data - Hunting for compounds with novel mechanisms using cellular high-throughput screening profiles with Grey Chemical Matter

Organosilicon Precursors for Efficient Aromatic Copper-Mediated Radiocyanation

13 results in Authors: Peter Scott