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Design of a potent, selective and brain penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit

Nicky Willis, William Mahy, James Sipthorp, Yuguang Zhao, Hannah Woodward, Benjamin Atkinson, Elliott Bayle, Fredrik Svensson, Sarah Frew, Fiona Jeganathan, Amy Monaghan, Stefano Benvegnu, Sarah Jolly, Luca Vecchia, Reinis Ruza, Svend Kjaer, Steven Howell, Ambrosius Snidjers, Magda Bictash, Patricia Salinas, Jean-Paul Vincent, Yvonne Jones, Paul Whiting, Paul Fish

Version 1 posted 16 March 2022

316

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Organic Chemistry

Working Paper

Readily Accessible Strained Difunctionalized trans-Cyclooctenes with Fast Click and Release Capabilities

Daan Sondag, Luuk Maartense, Heleen de Jong, Frank de Kleijne, Kim Bonger, Dennis Lowik, Thomas Boltje, Jan Dommerholt, Paul White, Daniel Blanco-Ania, Floris Rutjes

Version 1 posted 18 October 2022

425

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Analytical Chemistry

Working Paper

Trace Residue Identification, Characterization and Longitudinal Monitoring of the Novel Synthetic Opioid β-U10, from Discarded Drug Paraphernalia

Henry West, John Fitzgerald, Katherine Hopkins, Michael Leeming, Matthew Di Rago, Dimitri Gerostamoulos, Nicolas Clark, Paul Dietze, Jonathan White, James Ziogas, Gavin Reid

Version 1 posted 09 March 2022

218

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Catalysis

Working Paper

Prediction of enantioselectivity by monitoring reaction intermediates

Roelant Hilgers, Sin Yong Teng, Anamarija Bris, Aleksandr Y. Pereverzev, Paul White, Jeroen Jansen, Jana Roithova

Version 1 posted 13 April 2022

363

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Organic Chemistry

Working Paper

Hydroxy groups enhance [2]rotaxane anion binding selectivity

Rosemary Goodwin, Andrew Docker, Hugo MacDermott-Opeskin, Heather Aitken, Megan O'Mara, Paul Beer, Nicholas White

Version 1 posted 15 February 2022

234

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Organic Chemistry

Working Paper

Detection and Characterization of Rapidly Equilibrating Glycosylation Reaction Intermediates Using Exchange NMR

Frank de Kleijne, Floor ter Braak, Dimitrios Piperoudis, Peter Moons, Sam Moons, Hidde Elferink, Paul White, Thomas Boltje

Version 1 posted 11 July 2023

280

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1

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Analytical Chemistry

Working Paper

Effective Carbon Number and Inter-Class Retention Time Conversion Enhances Lipid Identifications in Untargeted Clinical Lipidomics

Jake White, Paul Trim, Thalia Salagaras, Aaron Long, Peter Psaltis, Johan Verjans, Marten Snel

Version 1 posted 30 August 2021

545

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Biological and Medicinal Chemistry

Working Paper

Encapsulation of Paramagnetic Chelates in Perfluorocarbon-loaded Fractal Nanoparticles Enables Modulation of Fluorine-19 and Proton Magnetic Resonance Imaging Signal

Margot Verbeelen, Paul White, Alexander H.J. Staal, Edyta Swider-Cios, Kimberly R.G. Cortenbach, N. Koen van Riessen, Cyril Cadiou, Françoise Chuburu, Mangala Srinivas, Olga Koshkina

Version 2 posted 28 July 2021

408

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8 results in Paul Whiting in Authors: Paul Whiting

Design of a potent, selective and brain penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit

Readily Accessible Strained Difunctionalized trans-Cyclooctenes with Fast Click and Release Capabilities

Trace Residue Identification, Characterization and Longitudinal Monitoring of the Novel Synthetic Opioid β-U10, from Discarded Drug Paraphernalia

Prediction of enantioselectivity by monitoring reaction intermediates

Hydroxy groups enhance [2]rotaxane anion binding selectivity

Detection and Characterization of Rapidly Equilibrating Glycosylation Reaction Intermediates Using Exchange NMR

Effective Carbon Number and Inter-Class Retention Time Conversion Enhances Lipid Identifications in Untargeted Clinical Lipidomics

Encapsulation of Paramagnetic Chelates in Perfluorocarbon-loaded Fractal Nanoparticles Enables Modulation of Fluorine-19 and Proton Magnetic Resonance Imaging Signal

8 results in Authors: Paul Whiting