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Biological and Medicinal Chemistry

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Paris Watson

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Biological and Medicinal Chemistry

Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers DS-103 as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties

Daniel Stopper, Lukas Biermann, Paris Watson, jingyu Li, Beate König, Matthew Gaynes, Lais Pessanha de Carvalho, Maria Hanl, Alexandra Hamacher, Linda Schäker-Hübner, Jana Held, David Christianson, Matthias Kassack, Finn Kristian Hansen

Version 1 posted 01 October 2024

454

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Biological and Medicinal Chemistry

Difluoromethyl-1,3,4-oxadiazoles are selective, mechanism-based, and essentially irreversible inhibitors of histone deacetylase 6

Beate König, Paris R. Watson, Nina Reßing, Abigail D. Cragin, Linda Schäker-Hübner, David W. Christianson, Finn Kristian Hansen

Version 4 posted 04 September 2023

1,362

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