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Diversity Oriented Clicking: Synthesis of beta-Substituted Alkenyl Sulfonyl Fluorides as Covalent Human Neutrophil Elastase Inhibitors

Yunfei Cheng, Gencheng Li, Christopher J. Smedley, Marie-Claire Giel, Seiya Kitamura, Jordan L. Woehl, Giulia Bianco, Stefano Forli, Joshua A. Homer, John R. Cappiello, Dennis W. Wolan, John E. Moses, K. Barry Sharpless

Version 1 posted 25 April 2022

645

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Biological and Medicinal Chemistry

Working Paper

Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides

Christopher J. Smedley, Bing Gao, Suhua Li, Qinheng Zheng, Andrew Molino, Hendrika M. Duivenvoorden, Belinda S. Parker, David J. D. Wilson, K. Barry Sharpless, John E. Moses

Version 3 posted 04 December 2018

1,389

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Biological and Medicinal Chemistry

Working Paper

SuFEx-Enabled High-Throughput Medicinal Chemistry

Seiya Kitamura, Qinheng Zheng, Jordan L. Woehl, angelo solan, Emily Chen, Nicholas Dillon, Mitchell Hull, Miyako Kotaniguchi, Shinichi Kitamura, Victor Nizet, K. Barry Sharpless, Dennis Wolan

Version 1 posted 20 December 2019

974

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Catalysis

Working Paper

Phosphorus(V) Fluoride Exchange (PFEx): Multidimensional Click Chemistry from Phosphorus(V) Connective Hubs

Shoujun Sun, Christopher J. Smedley, Joshua A. Homer, Qing-Qing Cheng, K. Barry Sharpless, John E. Moses

Version 1 posted 03 October 2022

2,793

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1

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Polymer Science

Working Paper

SuFExable Polymers with Helical Structures Derived from Thionyl Tetrafluoride (SOF4)

Suhua Li, Gencheng Li, Bing Gao, Sidharam P. Pujari, Xiaoyan Chen, Hyunseok Kim, Feng Zhou, Liana M. Klivansky, Yi Liu, Hafedh Driss, Rachael E. Impey, Tatiana P. Soares da Costa, Jianmei Lu, Peng Wu, Han Zuilhof, John E. Moses, K. Barry Sharpless

Version 1 posted 23 October 2019

1,105

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Biological and Medicinal Chemistry

Working Paper

“Sleeping Beauty” Phenomenon: SuFEx-Enabled Discovery of Selective Covalent Inhibitors of Human Neutrophil Elastase

Qinheng Zheng, Jordan L. Woehl, Seiya Kitamura, Diogo Santos-Martins, Christopher J. Smedley, Gencheng Li, Stefano Forli, John E. Moses, Dennis W. Wolan, K. Barry Sharpless

Version 1 posted 15 March 2019

1,665

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2

Citations

Biological and Medicinal Chemistry

Working Paper

[18F]SuFEx Click Chemistry Enabled Ultrafast Late-stage Radiosynthesis

Qinheng Zheng, Hongtao Xu, Hua Wang, Wen-Ge Han Du, Nan Wang, Huan Xiong, Yuang Gu, Louis Noodleman, Guang Yang, K. Barry Sharpless, Peng Wu

Version 2 posted 11 August 2020

1,994

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1

Citations

Polymer Science

Working Paper

Chain-Growth SuFEx Polycondensation: Molecular Weight Control and Synthesis of Degradable Polysulfates

Hyunseok Kim, Jiayu Zhao, Jinhye Bae, Liana M. Klivansky, Eric Dailing, Yi Liu, John R. Cappiello, K. Barry Sharpless, Peng Wu

Version 2 posted 12 August 2021

650

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Catalysis

Working Paper

Alkyl Sulfonyl Fluorides as Ambiphiles in the Stereoselective, Palladium(II)-Catalyzed Cyclopropanation of Unactivated Alkenes

Yilin Cao, Warabhorn Rodphon, Turki Alturaifi, Al Lisboa, Zhouyang Ren, Job Struijs, Hui-Qi Ni, Taras Savchuk, Pavel Mykhailiuk, Richard Loach, Shouliang Yang, Indrawan McAlpine, Donna Blackmond, Peng Liu, K. Barry Sharpless, Keary Engle

Version 1 posted 13 November 2024

735

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Refine Search

9 results in K. Barry Sharpless in Authors: K. Barry Sharpless

Diversity Oriented Clicking: Synthesis of beta-Substituted Alkenyl Sulfonyl Fluorides as Covalent Human Neutrophil Elastase Inhibitors

Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides

SuFEx-Enabled High-Throughput Medicinal Chemistry

Phosphorus(V) Fluoride Exchange (PFEx): Multidimensional Click Chemistry from Phosphorus(V) Connective Hubs

SuFExable Polymers with Helical Structures Derived from Thionyl Tetrafluoride (SOF4)

“Sleeping Beauty” Phenomenon: SuFEx-Enabled Discovery of Selective Covalent Inhibitors of Human Neutrophil Elastase

[18F]SuFEx Click Chemistry Enabled Ultrafast Late-stage Radiosynthesis

Chain-Growth SuFEx Polycondensation: Molecular Weight Control and Synthesis of Degradable Polysulfates

Alkyl Sulfonyl Fluorides as Ambiphiles in the Stereoselective, Palladium(II)-Catalyzed Cyclopropanation of Unactivated Alkenes

9 results in Authors: K. Barry Sharpless