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Multicomponent Syntheses Enable the Discovery of Novel Quisinostat-Derived Chemotypes as Histone Deacetylase Inhibitors

Daniel Stopper, Susanna Buntrock, Kathrin Tan, Lais Pessanha de Carvalho, Linda Schäker-Hübner, Jana Held, Matthias Kassack, Finn Kristian Hansen

Version 2 posted 07 November 2024

125

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Biological and Medicinal Chemistry

Working Paper

Preferential HDAC6 inhibitors derived from HPOB exhibit synergistic antileukemia activity in combination with decitabine

Maik Tretbar, Julian Schliehe-Diecks, Lukas von Bredow, Kathrin Tan, Martin Roatsch, Jia-Wey Tu, Marie Kemkes, Melf Sönnichsen, Andrea Schöler, Arndt Borkhardt, Sanil Bhatia, Finn Kristian Hansen

Version 2 posted 22 April 2024

323

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Biological and Medicinal Chemistry

Working Paper

Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers DS-103 as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties

Daniel Stopper, Lukas Biermann, Paris Watson, jingyu Li, Beate König, Matthew Gaynes, Lais Pessanha de Carvalho, Maria Hanl, Alexandra Hamacher, Linda Schäker-Hübner, Jana Held, David Christianson, Matthias Kassack, Finn Kristian Hansen

Version 1 posted 01 October 2024

264

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Biological and Medicinal Chemistry

Working Paper

Development and characterization of the first selective class IIb histone deacetylase degraders

Shiyang Zhai, Linda Schäker-Hübner, Maria Hanl, Lukas Jacobi, Dominika Ewa Pieńkowska, Jan Gerhartz, Rabea Voget, Michael Gütschow, Felix Meissner, Radosław P. Nowak, Christian Steinebach, Finn Kristian Hansen

Version 2 posted 28 August 2024

400

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Biological and Medicinal Chemistry

Working Paper

Development of the first non-hydroxamate selective HDAC6 degraders

Tim Keuler, Beate König, Nico Bückreiß, Fabian Kraft, Philipp König, Linda Schäker-Hübner, Christian Steinebach, Gerd Bendas, Michael Gütschow, Finn Kristian Hansen

Version 2 posted 24 August 2022

1,011

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Biological and Medicinal Chemistry

Working Paper

Difluoromethyl-1,3,4-oxadiazoles are selective, mechanism-based, and essentially irreversible inhibitors of histone deacetylase 6

Beate König, Paris R. Watson, Nina Reßing, Abigail D. Cragin, Linda Schäker-Hübner, David W. Christianson, Finn Kristian Hansen

Version 4 posted 04 September 2023

993

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Biological and Medicinal Chemistry

Working Paper

Groebke Blackburn Bienaymé-mediated multi-component synthesis of selective HDAC6 inhibitors with anti-inflammatory properties

Fabian Kraft, Jana Enns, Irina Honin, Jonas Engelhardt, Andrea Schöler, Shannon Smith, Jens Meiler, Linda Schäker-Hübner, Günther Weindl, Finn Kristian Hansen

Version 2 posted 19 December 2023

229

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Biological and Medicinal Chemistry

Working Paper

Development of Peptoid-Based Heteroaryl-Decorated Histone Deacetylase (HDAC) Inhibitors with Dual-Stage Antiplasmodial Activity

Daniel Stopper, Lais Pessanha de Carvalho, Mariana Laureano de Souza, Cindy-Esther Kponomaizoun, Elizabeth Winzeler, Jana Held, Finn Kristian Hansen

Version 2 posted 09 August 2024

234

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Biological and Medicinal Chemistry

Working Paper

Hydrazide-based class I HDAC inhibitors with HDAC3 preference completely reverse chemoresistance in a synergistic manner in platinum-resistant solid cancer cells

Fabian B. Kraft, Lukas Biermann, Linda Schäker-Hübner, Maria Hanl, Alexandra Hamacher, Matthias U. Kassack, Finn Kristian Hansen

Version 2 posted 02 August 2024

313

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Biological and Medicinal Chemistry

Working Paper

Development of the First-in-Class FEM1B-Recruiting Histone Deacetylase Degraders

Felix Feller, Irina Honin, Martina Miranda, Heiko Weber, Svenja Henze, Maria Hanl, Finn Kristian Hansen

Version 1 posted 23 October 2024

337

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10 results in Finn Kristian Hansen in Authors: Finn Kristian Hansen

Multicomponent Syntheses Enable the Discovery of Novel Quisinostat-Derived Chemotypes as Histone Deacetylase Inhibitors

Preferential HDAC6 inhibitors derived from HPOB exhibit synergistic antileukemia activity in combination with decitabine

Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers DS-103 as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties

Development and characterization of the first selective class IIb histone deacetylase degraders

Development of the first non-hydroxamate selective HDAC6 degraders

Difluoromethyl-1,3,4-oxadiazoles are selective, mechanism-based, and essentially irreversible inhibitors of histone deacetylase 6

Groebke Blackburn Bienaymé-mediated multi-component synthesis of selective HDAC6 inhibitors with anti-inflammatory properties

Development of Peptoid-Based Heteroaryl-Decorated Histone Deacetylase (HDAC) Inhibitors with Dual-Stage Antiplasmodial Activity

Hydrazide-based class I HDAC inhibitors with HDAC3 preference completely reverse chemoresistance in a synergistic manner in platinum-resistant solid cancer cells

Development of the First-in-Class FEM1B-Recruiting Histone Deacetylase Degraders

10 results in Authors: Finn Kristian Hansen