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Preferential HDAC6 inhibitors derived from HPOB exhibit synergistic antileukemia activity in combination with decitabine

Maik Tretbar, Julian Schliehe-Diecks, Lukas von Bredow, Kathrin Tan, Martin Roatsch, Jia-Wey Tu, Marie Kemkes, Melf Sönnichsen, Andrea Schöler, Arndt Borkhardt, Sanil Bhatia, Finn Kristian Hansen

Version 2 posted 22 April 2024

323

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Biological and Medicinal Chemistry

Working Paper

Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers DS-103 as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties

Daniel Stopper, Lukas Biermann, Paris Watson, jingyu Li, Beate König, Matthew Gaynes, Lais Pessanha de Carvalho, Maria Hanl, Alexandra Hamacher, Linda Schäker-Hübner, Jana Held, David Christianson, Matthias Kassack, Finn Kristian Hansen

Version 1 posted 01 October 2024

264

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Biological and Medicinal Chemistry

Working Paper

Multicomponent Syntheses Enable the Discovery of Novel Quisinostat-Derived Chemotypes as Histone Deacetylase Inhibitors

Daniel Stopper, Susanna Buntrock, Kathrin Tan, Lais Pessanha de Carvalho, Linda Schäker-Hübner, Jana Held, Matthias Kassack, Finn Kristian Hansen

Version 2 posted 07 November 2024

125

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Biological and Medicinal Chemistry

Working Paper

Groebke Blackburn Bienaymé-mediated multi-component synthesis of selective HDAC6 inhibitors with anti-inflammatory properties

Fabian Kraft, Jana Enns, Irina Honin, Jonas Engelhardt, Andrea Schöler, Shannon Smith, Jens Meiler, Linda Schäker-Hübner, Günther Weindl, Finn Kristian Hansen

Version 2 posted 19 December 2023

229

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Biological and Medicinal Chemistry

Working Paper

Development of Peptoid-Based Heteroaryl-Decorated Histone Deacetylase (HDAC) Inhibitors with Dual-Stage Antiplasmodial Activity

Daniel Stopper, Lais Pessanha de Carvalho, Mariana Laureano de Souza, Cindy-Esther Kponomaizoun, Elizabeth Winzeler, Jana Held, Finn Kristian Hansen

Version 2 posted 09 August 2024

234

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Biological and Medicinal Chemistry

Working Paper

Development and characterization of the first selective class IIb histone deacetylase degraders

Shiyang Zhai, Linda Schäker-Hübner, Maria Hanl, Lukas Jacobi, Dominika Ewa Pieńkowska, Jan Gerhartz, Rabea Voget, Michael Gütschow, Felix Meissner, Radosław P. Nowak, Christian Steinebach, Finn Kristian Hansen

Version 2 posted 28 August 2024

400

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Biological and Medicinal Chemistry

Working Paper

Hydrazide-based class I HDAC inhibitors with HDAC3 preference completely reverse chemoresistance in a synergistic manner in platinum-resistant solid cancer cells

Fabian B. Kraft, Lukas Biermann, Linda Schäker-Hübner, Maria Hanl, Alexandra Hamacher, Matthias U. Kassack, Finn Kristian Hansen

Version 2 posted 02 August 2024

313

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Biological and Medicinal Chemistry

Working Paper

Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs

Christian Steinebach, Izidor Sosič, Aleša Bricelj, Arunima Murgai, Luca Bischof, Yuen Lam Dora Ng, Christopher Heim, Samuel Maiwald, Matic Proj, Rabea Voget, Felix Feller, Janez Košmrlj, Annika Schmidt, Patricia Lemnitzer, Finn K. Hansen, Michael Gütschow, Jan Krönke, Marcus D. Hartmann

Version 1 posted 21 April 2023

1,597

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1

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Biological and Medicinal Chemistry

Working Paper

Fluorescent Ligand Enables Target Engagement Studies for the Intracellular Allosteric Binding Site of the Chemokine Receptor CXCR2

Max Huber, Silas Wurnig, Lara Toy, Corinna Weiler, Nicole Merten, Evi Kostenis, Finn Hansen, Matthias Schiedel

Version 4 posted 28 April 2023

455

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Biological and Medicinal Chemistry

Working Paper

Difluoromethyl-1,3,4-oxadiazoles are selective, mechanism-based, and essentially irreversible inhibitors of histone deacetylase 6

Beate König, Paris R. Watson, Nina Reßing, Abigail D. Cragin, Linda Schäker-Hübner, David W. Christianson, Finn Kristian Hansen

Version 4 posted 04 September 2023

993

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Refine Search

15 results in Finn Hansen in Authors: Finn Hansen

Preferential HDAC6 inhibitors derived from HPOB exhibit synergistic antileukemia activity in combination with decitabine

Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers DS-103 as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties

Multicomponent Syntheses Enable the Discovery of Novel Quisinostat-Derived Chemotypes as Histone Deacetylase Inhibitors

Groebke Blackburn Bienaymé-mediated multi-component synthesis of selective HDAC6 inhibitors with anti-inflammatory properties

Development of Peptoid-Based Heteroaryl-Decorated Histone Deacetylase (HDAC) Inhibitors with Dual-Stage Antiplasmodial Activity

Development and characterization of the first selective class IIb histone deacetylase degraders

Hydrazide-based class I HDAC inhibitors with HDAC3 preference completely reverse chemoresistance in a synergistic manner in platinum-resistant solid cancer cells

Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs

Fluorescent Ligand Enables Target Engagement Studies for the Intracellular Allosteric Binding Site of the Chemokine Receptor CXCR2

Difluoromethyl-1,3,4-oxadiazoles are selective, mechanism-based, and essentially irreversible inhibitors of histone deacetylase 6

15 results in Authors: Finn Hansen