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Biological and Medicinal Chemistry

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Anna K. H. Hirsch

13 results in Authors: Anna K. H. Hirsch

Biological and Medicinal Chemistry

Strategies on Designing Thiamine Analogues for Inhibition of Thiamine Diphosphate (ThDP)-dependent Enzymes: Systematic Investigation through Scaffold Switching and C2-Functionalisation

Alex H. Y. Chan, Terence C. S. Ho, Rimsha Irfan, Rawia A. A. Hamid, Emma S. Rudge, Amjid Iqbal, Alex Turner, Anna K. H. Hirsch, Finian James Leeper

308

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Biological and Medicinal Chemistry

Targeting Plasmodium falciparum IspD in the Methyl-D-Erythritol Phosphate Pathway: Urea-Based Compounds with Nanomolar Potency on target with low micromolar whole-cell activity

Daan Willocx, Lorenzo Bizzarri, Alaa Alhayek, Patricia Bravo, Boris Illarionov, Katharina Rox, Jonas Lohse, Markus Fischer, Andreas M. Kany, Hannes Hahne, Matthias Rottmann, Matthias Witschel, Mostafa M. Hamed, Eleonora Diamanti, Anna K. H. Hirsch

171

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Biological and Medicinal Chemistry

An efficient way to screen inhibitors of energy-coupling factor (ECF) transporters in bacteria uptake assay

Spyridon Bousis, Steffen Winkler, Jörg Haupenthal, Francesco Fulco, Eleonora Diamanti, Anna K. H. Hirsch

237

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1

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Biological and Medicinal Chemistry

A Positive Charge in an Antimalarial Compound Unlocks Broad-spectrum Antibacterial Activity

Maria Braun-Cornejo, Mitchell Platteschorre, Vincent de Vries, Patricia Bravo, Vidhisha Sonawane, Mostafa M. Hamed, Jörg Haupenthal, Norbert Reiling, Matthias Rottmann, Dennis Piet, Peter Maas, Eleonora Diamanti, Anna K. H. Hirsch

303

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Biological and Medicinal Chemistry

New Genetically Engineered Derivatives of Antibacterial Darobac-tins Underpin their Potential for Antibiotic Development

Carsten E. Seyfert, Alison V. Müller, Danica J. Walsh, Joy Birkelbach, Andreas M. Kany, Christoph Porten, Biao Yuan, Daniel Krug, Jennifer Herrmann, Thomas C. Marlovits, Anna K. H. Hirsch, Rolf Müller

273

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1

Citations

Clean synthetic strategies to dopamine-based biologically active molecules from lignin: A green path to drug discovery

Anastasiia Afanasenko, Xianyuan Wu, Alessandra DeSanti, Walid Elgaher, Andreas M. Kany, Roya Shafiei, Marie-Sophie Schulze, Thomas Schulz, Jörg Haupenthal, Anna K. H. Hirsch, Katalin Barta

710

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3

Citations

Biological and Medicinal Chemistry

Evaluation of Ketoclomazone and its Analogues as Inhibitors of Thiamine Diphosphate (ThDP)-dependent Enzymes

Alex H. Y. Chan, Terence C. S. Ho, Imam Fathoni, Rawia Hamid, Anna K. H. Hirsch, Kevin J. Saliba, Finian James Leeper

185

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Biological and Medicinal Chemistry

Target-directed dynamic combinatorial chemistry affords inhibitors of Nsp10 as potential antivirals against SARS-CoV-2

Ravindra P. Jumde, Gwenaëlle Jézéquel, Margarida Saramago, Nicolas Frank, Sebastian Adam, Marta V. Cunha, Chantal Bader, Antonia P. Gunesch, Natalie M. Köhler, Sandra Johannsen, Thomas Pietschmann, Rute G. Matos, Rolf Müller, Cecilia M. Arraiano, Anna K. H. Hirsch

348

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Biological and Medicinal Chemistry

Structure-Guided Optimization of Small-Molecule Folate Uptake Inhibitors Targeting the Energy-Coupling Factor Transporters

Alexander F. Kiefer, Spyridon Bousis, Mostafa M. Hamed, Eleonora Diamanti, Jörg Haupenthal, Anna K. H. Hirsch

224

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1

Citations

Biological and Medicinal Chemistry

Identification of three new inhibitor classes against Plasmodium falciparum

Sandra Johannsen, Robin M. Gierse, Arne Krüger, Rachel L. Edwards, Vittoria Nanna, Anna Fontana, Di Zhu, Tizina Masini, Lais Pessanha de Carvalho, Mael Poizat, Bart Kieftenbelt, Dana M. Hodge, Sophie Alvarez, Daan Bunt, Kamila Anna Meissner, Edmarcia Elisa de Souza, Melloney Dröge, Bernard van Vliet, Jack de Hartog, Michael C. Hutter, Jana Held, Audrey R. Odom John, Carsten Wrenger, Anna K. H. Hirsch

377

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