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Catalysis

Working Paper

Catalytic Enantioselective Synthesis of Heterocyclic Vicinal Fluoroamines Using Asymmetric Protonation: A Method Development and Mechanistic Study

Matthew Ashford, Chao Xu, john molloy, Cameron Carpenter-Warren, Alexandra Slawin, Andrew Leach, Allan Watson

Version 1 posted 03 March 2020

757

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Inorganic Chemistry

Working Paper

Palladium and platinum 2,4-cis-amino azetidine and related complexes

Akina Yoshizawa, Antonio Feula, Andrew G. Leach, Louise Male, John Fossey

Version 1 posted 06 April 2018

289

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1

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Organic Chemistry

Working Paper

A Mechanistic Analysis of Trimethylanilinium Salt Degradation: Implications for Methylation and Cross-coupling Applications

Jack B. Washington, Michele Assante, Chunhui Yan, David McKinney, Vanessa Juba, Andrew Leach, Sharon E. Baillie, Marc Reid

Version 1 posted 02 February 2021

384

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Biological and Medicinal Chemistry

Working Paper

Boronic ester derivative-dependent activity of parthenolide analogues

Xingjian Li, George Williams, Alex Quy, Yiming Zhao, Louise Male, Eric Anslyn, Tatjana Stankovic, Andrew Leach, Angelo Agathanggelou, John Fossey

Version 2 posted 28 October 2021

489

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Biological and Medicinal Chemistry

Working Paper

Pharmacological Evaluation of Enantiomers of AZ11645373 against the P2X7 Receptor

Andrew Mcgown, Nicolas Renault, Amélie Barczyk, Jordan Nafie, Luciano Barluzzi, Daniel Guest, Graham Tizzard, Simon Coles, David Leach, Daniel von Emloh, Lea Sutton, Kiera Bailey, Lewis Edmunds, Barnaby Greenland, Régis Millet, John Spencer, Xavier Dezitter

Version 2 posted 16 October 2024

120

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Biological and Medicinal Chemistry

Working Paper

Excuse me, there is a mutant in my bioactivity soup! A comprehensive analysis of the genetic variability landscape of bioactivity databases and its effect on activity modelling

Marina Gorostiola González, Olivier J. M. Béquignon, Emma Manners, Anna Gaulton, Prudence Mutowo, Elisabeth Dawson, Barbara Zdrazil, Andrew R. Leach, Adriaan P. IJzerman, Laura H. Heitman, Gerard J. P. van Westen

Version 1 posted 24 June 2024

228

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Biological and Medicinal Chemistry

Working Paper

Occurrence of ‘Natural Selection’ in Successful Small Molecule Drug Discovery

Lina Heinzke, Axel Pahl, Barbara Zdrazil, Andrew Leach, Herbert Waldmann, Robert Young, Paul Leeson

Version 1 posted 25 March 2024

433

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Theoretical and Computational Chemistry

Working Paper

A compound-target pairs dataset: differences between drugs, clinical candidates and other bioactive compounds

A. Lina Heinzke, Barbara Zdrazil, Paul D. Leeson, Robert J. Young, Axel Pahl, Herbert Waldmann, Andrew R. Leach

Version 2 posted 11 March 2024

605

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1

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Catalysis

Working Paper

Asymmetric synthesis of heterocyclic chloroamines and aziridines by enantioselective protonation of catalytically generated enamines

Liam McLean, Matthew Ashford, James Fyfe, Alexandra Slawin, Andrew Leach, Allan Watson

Version 1 posted 14 September 2021

787

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Organic Chemistry

Working Paper

Enantiomer stability of atropisomeric 1,5-disubstituted 1,2,3-triazoles

Fernanda Meloni, William Brittain, Louise Male, Cécile Le Duff, Benjamin Buckley, Andrew Leach, John Fossey

Version 1 posted 25 October 2021

464

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14 results in Andrew Leach in Authors: Andrew Leach

Catalytic Enantioselective Synthesis of Heterocyclic Vicinal Fluoroamines Using Asymmetric Protonation: A Method Development and Mechanistic Study

Palladium and platinum 2,4-cis-amino azetidine and related complexes

A Mechanistic Analysis of Trimethylanilinium Salt Degradation: Implications for Methylation and Cross-coupling Applications

Boronic ester derivative-dependent activity of parthenolide analogues

Pharmacological Evaluation of Enantiomers of AZ11645373 against the P2X7 Receptor

Excuse me, there is a mutant in my bioactivity soup! A comprehensive analysis of the genetic variability landscape of bioactivity databases and its effect on activity modelling

Occurrence of ‘Natural Selection’ in Successful Small Molecule Drug Discovery

A compound-target pairs dataset: differences between drugs, clinical candidates and other bioactive compounds

Asymmetric synthesis of heterocyclic chloroamines and aziridines by enantioselective protonation of catalytically generated enamines

Enantiomer stability of atropisomeric 1,5-disubstituted 1,2,3-triazoles

14 results in Authors: Andrew Leach