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New Genetically Engineered Derivatives of Antibacterial Darobac-tins Underpin their Potential for Antibiotic Development

Carsten E. Seyfert, Alison V. Müller, Danica J. Walsh, Joy Birkelbach, Andreas M. Kany, Christoph Porten, Biao Yuan, Daniel Krug, Jennifer Herrmann, Thomas C. Marlovits, Anna K. H. Hirsch, Rolf Müller

Version 1 posted 11 September 2023

229

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1

Citations

Biological and Medicinal Chemistry

Working Paper

Unlocking the Antiviral Arsenal: Multiparametric Optimization of Small-Molecule Inhibitors against RSV and hCoV-229E

Christina Karhan, Svenja Mareike Sake, Antonia Patricia Gunesch, Christina Grethe, Benedikt Hellwinkel, Alexander Felix Kiefer, Uladzislau Hapko, Andreas Martin Kany, Thomas Pietschmann, Anna Katharina Herta Hirsch

Version 1 posted 13 February 2024

200

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Biological and Medicinal Chemistry

Working Paper

Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening

Di Zhu, Sandra Johannsen, Tiziana Masini, Céline Simonin, Jörg Haupenthal, Boris Illarionov, Anastasia Andreas, Mahendra Awale, Robin M. Gierse, Tridia van der Laan, Ramon van der Vlag, Rita Nasti, Mael Poizat, Eric Buhler, Norbert Reiling, Rolf Müller, Markus Fischer, Jean-Louis Reymond, Anna K. H. Hirsch

Version 2 posted 11 April 2022

364

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Biological and Medicinal Chemistry

Working Paper

Inhibitors of the Elastase LasB for the treatment of Pseudomonas aeruginosa lung infections

Jelena Konstantinovic, Andreas M. Kany, Alaa Alhayek, Ahmed S. Abdelsamie, Asfandyar Sikandar, Katrin Voos, Yiwen Yao, Anastasia Andreas, Roya Shafiei, Brigitta Loretz, Esther Schönauer, Robert Bals, Hans Brandstetter, Rolf W. Hartmann, Christian Ducho, Claus-Michael Lehr, Christoph Beisswenger, Rolf Müller, Katharina Rox, Jörg Haupenthal, Anna Katharina Herta Hirsch

Version 1 posted 24 April 2023

357

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Biological and Medicinal Chemistry

Working Paper

Selective Activation of TRPC6 Ion Channel by Metallated Type-B Polyprenylated Polycyclic Acylphloroglucinols

Philipp Peslalz, Frank Kraus, Flavia Izzo, Anton Bleisch, Yamina El Hamdaoui, Ina Schulz, Andreas Kany, Anna Hirsch, Kristina Friedland, Bernd Plietker

Version 1 posted 02 June 2023

189

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Catalysis

Working Paper

Clean synthetic strategies to dopamine-based biologically active molecules from lignin: A green path to drug discovery

Anastasiia Afanasenko, Xianyuan Wu, Alessandra DeSanti, Walid Elgaher, Andreas M. Kany, Roya Shafiei, Marie-Sophie Schulze, Thomas Schulz, Jörg Haupenthal, Anna K. H. Hirsch, Katalin Barta

Version 1 posted 18 October 2022

592

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3

Citations

Organic Chemistry

Working Paper

Enhancing Glycan Stability via Site-Selective Fluorination: Modulating Substrate Orientation by Molecular Design.

Alexander Axer, Ravindra P. Jumde, Sebastian Adam, Andreas Faust, Michael Schäfers, Manfred Fobker, Jesko Koehnke, Anna K.H. Hirsch, Ryan Gilmour

Version 1 posted 15 July 2020

497

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Materials Science

Working Paper

Molecular Embroidering of Graphene

Tao Wei, Malte Kohring, Heiko B. Weber, Frank Hauke, Andreas Hirsch

Version 1 posted 11 May 2020

451

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Theoretical and Computational Chemistry

Working Paper

DockM8: An All-in-One Open-Source Platform for Consensus Virtual Screening in Drug Design

Antoine Lacour, Hamza Ibrahim, Andrea Volkamer, Anna K. H. Hirsch

Version 1 posted 23 July 2024

519

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Biological and Medicinal Chemistry

Working Paper

Target-Directed Dynamic Combinatorial Chemistry Affords Binders of Mycobacterium Tuberculosis IspE

Maria Braun-Cornejo, Camilla Ornago, Vidhisha Sonawane, Jörg Haupenthal, Andreas M. Kany, Eleonora Diamanti, Gwenaëlle Jézéquel, Norbert Reiling, Wulf Blankenfeldt, Peter Maas, Anna K. H. Hirsch

Version 1 posted 20 May 2024

84

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13 results in Andreas Hirsch in Authors: Andreas Hirsch

New Genetically Engineered Derivatives of Antibacterial Darobac-tins Underpin their Potential for Antibiotic Development

Unlocking the Antiviral Arsenal: Multiparametric Optimization of Small-Molecule Inhibitors against RSV and hCoV-229E

Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening

Inhibitors of the Elastase LasB for the treatment of Pseudomonas aeruginosa lung infections

Selective Activation of TRPC6 Ion Channel by Metallated Type-B Polyprenylated Polycyclic Acylphloroglucinols

Clean synthetic strategies to dopamine-based biologically active molecules from lignin: A green path to drug discovery

Enhancing Glycan Stability via Site-Selective Fluorination: Modulating Substrate Orientation by Molecular Design.

Molecular Embroidering of Graphene

DockM8: An All-in-One Open-Source Platform for Consensus Virtual Screening in Drug Design

Target-Directed Dynamic Combinatorial Chemistry Affords Binders of Mycobacterium Tuberculosis IspE

13 results in Authors: Andreas Hirsch