Synthesis and Evaluation Hydrogen-Bonding Organocatalysts Bearing P(V)-Stereogenic Centers

In this study, we report the synthesis of a novel series of chiral hybrid scaffolds, each featuring a P(V)-stereogenic center integrated with a chiral backbone via squaramide or thiourea linkers. The catalytic performance of these newly developed organocatalysts was evaluated in asymmetric transfer hydrogenation reactions, revealing moderate activity and limited selectivity.