Point to Axial Chirality Transfer: Asymmetric Synthesis of Substi-tuted 1-Aza-Spiro [2,3]-Hexanes and Spiro Thiazolidinethiones

Synthesis of chiral 1-aza-spiro [2,3]-hexanes and spiro thiazolidinethiones possessing axial as well as point chirality was accomplished by transfer of point group chirality to axial chirality without losing the point chirality. The process involved Cs2CO3 mediated ring opening of the bicyclobutane derivatives containing the chiral sulfinamides prepared from Ellman sulfin-imines. The procedure is operationally simple, does not involve either expensive multi-metal catalysis or arduous experimental procedures/ transformations.