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Total Synthesis of Tetrasaccharide Repeating Units of Pseudomonas aeruginosa (Lányi) O11

13 June 2025, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Herein, we report the first total synthesis of the conjugation-ready tetrasaccharide repeating unit of Pseudomonas aeruginosa O11 Lányi 170021. The installation of three consecutive 1,2-cis linkages is addressed here. The synthesis of the tetrasaccharide repeating unit of Pseudomonas aeruginosa O11 170021 (Lányi) is accomplished via the longest linear sequences of 22 steps in 3.2% overall yield using the efficient (2+2) strategy. The devolved (2+2) strategy will facilitate the synthesis of the structurally related tetrasaccharide RU of Pseudomonas aeruginosa O11 170040.

Keywords

bacterial lipooligosaccharides
repeating units
vaccines

Supplementary materials

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Description
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Supporting Information
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All characterization data and copies of spectra
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Version History

Jun 13, 2025 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2025-wgrft
D O I: 10.26434/chemrxiv-2025-wgrft [opens in a new tab]

Funding

Science and Education research Board
SPR/2021/000328
CSIR
02(0413)/21/EMR-II

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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