Photocatalytic Late-Stage Decarboxylative Functionalization of Bioactive, Naturally Occurring, and Fatty Acids via gem-Borylsilyl Alkene

In this study, we report a photocatalytic late-stage decarboxylative functionalization strategy utilizing gem-boryl,silyl (gem-B,Si) alkene as a versatile coupling partner. This light-driven transformation enables the direct conversion of structurally simple and complex carboxylic acids into synthetically valuable molecules with Csp³ carbon bearing both Bpin and SiMe₃ groups under mild conditions. This methodology provides a powerful platform for the selective, programmable, late-stage modification of bioactive molecules, natural products, and fatty acid derivatives, enabling access to a diverse array of functionalized, chiral Csp³-rich molecules with potential applications across materials science and chemistry.