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Photochemical Metal-free Hydrocarbamoylation of Allylamines

13 June 2025, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We report a photoredox-catalysed protocol for allylamine hydrocarbamoylation under metal-free and mild conditions. The proposed method utilises readily accessible 4-carboxyamido Hantzsch esters as convenient substrates that deliver carbamoyl radicals upon a visible light-mediated SET process. Their combination with different allylamines worked well, producing the desired γ-amino acid amides efficiently and with a high degree of selectivity.

Keywords

photoredox catalysis
amides
amino acid derivatives
amino acids
hydrocarbamoylation
carbamoyl radicals

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Version History

Jun 13, 2025 Version 1

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The content is available under CC BY NC 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2025-dd94q
D O I: 10.26434/chemrxiv-2025-dd94q [opens in a new tab]

Funding

National Science Centre (Poland)
Grant OPUS 2021/43/B/ST4/01915

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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