Synthesis of 4- and 5-Aminotriazolamers via Iterative Electrophilic Ethynylation and Azide–Alkyne Cycloaddition

Nonpeptidic foldamers derived from amino acids, i.e., 4- and 5-aminotriazolamers, were synthesized via the assembly of three amino acid-derived modules, which was achieved through the copper-catalyzed ethynylation of amino acid-derived sulfonamides with triisopropylsilyl ethynylbenziodoxolone and copper- or ruthenium-catalyzed azide–alkyne cycloadditions with amino acid-derived azide-sulfonamides. The X-ray crystallograhic analysis of cyclic 4- and 5-aminotriazolamers revealed their porous structure.