Divergent Pathways in C–H Functionalization of Furfural Derivatives with Cobalt-Hydride Catalysis

06 June 2025, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

This study reports the first cobalt-catalysed C–H functionalization of furfural derivatives, demonstrating distinct reactivities based on the substrate. Furfurylimines enable selective C5–H alkenylation with alkynes, whereas free aldehydes undergo decarbonylative C2-alkenylation. These results establish a novel strategy using formyl groups as traceless handles for cobalt- catalysed C–C bond formation.

Keywords

Furfural
Cobalt
C-H activation

Supplementary materials

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