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Anti-Breast Cancer Stem Cell Activity of Titanocene Complexes of Non-Steroidal Anti-Inflammatory Drugs

03 June 2025, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Titanocene(IV)-NSAID complexes Cp2Ti(mefenamate)2 (4) and Cp2Ti(flufenamate)2 (5) show enhanced redox stability and potent cytotoxicity against breast cancer stem cells (CSCs), with 5 rivaling salinomycin and cisplatin. Complex 5 induces DNA damage and apoptosis, and its nanoparticle encapsulation improves biocompatibility. This is the first report targeting breast CSCs with titanocene-based metallodrugs.

Keywords

titanocenes
cancer stem cells
polymeric nanoparticles

Supplementary materials

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Description
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Title
Electronic Supplementary Information
Description
Experimental details. Additional synthesis and characterisation data (NMR, MS, CV, IR, XRD). Additional biological data.
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Version History

Jun 03, 2025 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2025-0bclj
D O I: 10.26434/chemrxiv-2025-0bclj [opens in a new tab]

Funding

Engineering and Physical Sciences Research Council
EP/Y002695/1
Engineering and Physical Sciences Research Council
EP/Y002695/1
Engineering and Physical Sciences Research Council
EP/V034766/1

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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