Hydrogen Bond-Controlled Site-Selective C–H Borylation at the Remote-Position of Naphthalene Derivatives

We successfully developed site-selective C–H borylation at the remote position (7-position) of naphthalene derivatives, which was controlled by hydrogen bonding between the substrate-recognition site of the catalyst (hydrogen bond donor) and the functional group of the substrate (hydrogen bond acceptor). This is the first example of site-selective C–H boryla-tion at a remote position of naphthalene and anthracene derivatives. By changing the ligands, the reaction sites can be switched, and site-selective remote C–H borylation of naphthalene derivatives with a functional group at the 1- or 2-position can be achieved.