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N-N Bond Formation Through N-H Dehydrocoupling

16 May 2025, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

N-N bond formation from amines can be accomplished through proton/electron transfer using simple base and oxidant combinations, where kinetic limitations related to the BDFE(eff) of a particular base/oxidant pair can be overcome using Lewis acid catalysts such as FeCl3.

Keywords

indazole
dehydrocoupling
bond dissociation free energy
oxidation

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Version History

May 16, 2025 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2025-vtv4x
D O I: 10.26434/chemrxiv-2025-vtv4x [opens in a new tab]

Funding

National Institutes of Health
R35GM119457
National Institutes of Health
S10OD011952
National Science Foundation
CHE-1336940
National Science Foundation
MRI-1229400

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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