Double Deoxygenative Coupling of Carboxylic Acids and Alcohols

Ketones are highly valued for their ability to engage in numerous functional group interconversions. However, the synthesis of complex ketones is traditionally limited by the need to employ organometallic reagents or pre-synthesize an activated component. Herein, we report a photoredox-catalyzed, double deoxygenative fragment coupling of alcohols and carboxylic acids that provides rapid access to sp3-rich ketone scaffolds. We further highlight new avenues for C1 logic through a bis-radical SOMO stitching approach that delivers ketone products from two alcohol substrates.