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NIR-triggered DNA etheno adducts photorepair with upconversion nanohybrids

05 May 2025, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Here, we report NIR-triggered photorepair of DNA damages via photosensitization by using well-known upconversion nanohybrids consisting of ytterbium and erbium co-doped core-shell upconversion nanoparticles (UCs) and rose Bengal (UC@RB). Specifically, two purine-derived etheno adducts (1,N6-etheno-2’-deoxyadenosine (εdA) and 1,N2-etheno-2’-deoxyguanosine (εdG)) have been used as proof of concept.

Keywords

Upconversion nanoparticles
DNA lesion
Photosensitization
Singlet Oxygen
DNA Repair

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Version History

May 05, 2025 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2025-n6749
D O I: 10.26434/chemrxiv-2025-n6749 [opens in a new tab]

Funding

MICIN/AEI/10.13039/501100011033/ and “FEDER a way of making Europe”
PID 2021-128348NB-I00
MICIN/AEI/10.13039/501100011033/ and “FEDER a way of making Europe”
PID2023-152131NB-I00
MICIN/AEI/10.13039/501100011033/ and “FEDER a way of making Europe”
CEX 2021-001230-S
MICIN/AEI/10.13039/501100011033/ and “FEDER a way of making Europe”
CEX2024-001467-M
MCIU, AEI and FSE+
RYC2023-043859-I
MICIN with funding from European Union NextGenerationEU (PRTR-C17.I1)
MFA/2022/051
Generalitat Valenciana
IDIFEDER/2018/064
Generalitat Valenciana
IDIFEDER/2021/064
Generalitat Valenciana
CIPROM/2022/57

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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