Bioselective Materials

This paper explores the innovative strategies in biomaterial engineering aimed at enhancing tissue regeneration through bioselective materials. It introduces the concept of bioselectivity, which is the ability of materials to interact selectively with specific biological entities, thereby promoting desired cellular responses while inhibiting unwanted ones. For example the review categorizes bioselective materials into 5 types: BSEL1, which enhances mammalian cell adhesion while reducing microbial colonization, particularly for bone implants; BSEL2, which selectively promotes tissue-specific mammalian cell growth for soft tissue scaffolds; and BSEL3, which balances tissue-forming and tissue-breaking cells to maintain bone integrity. The types, BSEL4 and BSEL5 materials are very futuristic materials as they can impart controlled cellular colonization to replicate the native extracellular matrix and mitigate issues such as fibrosis and immune reactions. Overall, the perspective review highlight the potential of bioselective materials in advancing regenerative medicine and improving the efficacy of tissue engineering solutions