Analyzing enzyme kinetics using a growth model

Dynamics of population growth or enzyme kinetics do not follow a constant rate making them difficult to quantify. Therefore, a single measure of dynamics is desired to profile the kinetic activities of enzymes with respect to various substrates. In this work, we use a growth model to model enzyme kinetics and provide a measure for kinetic activity based on the model parameters. This growth model, named the a − m model, has been fitted on nonlinear growth data of populations including bacterial colonies and longitudinal growth data of a human male. We apply the a − m growth model to fit and interpret the publicly available protease kinetic data provided by the developers of the protease activity analysis(PAA) toolkit. The results are summarized and interpreted using a growth coordinate system on an xy− plane.