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Abstract
Herein, we report a high-yielding nickel/photoredox-catalyzed amidine arylation method that accommodates a wide range of aryl halides and amidines. The method exhibits good functional group tolerance enabling its successful application to both simple substrates and late-stage functionalization experiments. Mechanistic studies revealed the pivotal role of an in situ generated triazine co-catalyst. This information allowed us to further optimize the protocol, achieving faster reaction rates, milder conditions, and most importantly the substrate scope was expanded to sulfonamides and primary amines as well.
Supplementary materials
Title
Experimental data
Description
SI for experimental data for screening and optimization, reaction scope and mechanistic investigations.
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Title
NMR spectra
Description
Copies of NMR (1H, 13C, and 2D where relevant) spectra of isolated compounds.
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