Electrochemical Deoxygenative Silylation of Alcohols

01 April 2025, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Alcohols are highly common organic compounds but remain scarce as alkyl donors in synthetic procedures. Here, we describe an electrochemical procedure for their deoxygenative cross-electrophile coupling with hydrosilanes, furnishing organosilane products in good to excellent yields. Mechanistic studies provide insights into the operating pathways of this semi-paired electrolytic transformation, suggesting that silyl ethers are likely reaction intermediates. Furthermore, a unified mechanistic proposal is presented that accounts for observed reactivity differences compared to analogous deoxygenative electrocarboxylation.

Keywords

electrosynthesis
alcohols
silylation
deoxygenation
reduction

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