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Cobaltaelectro-Catalyzed C-H Acyloxylation of Aromatic and Vinylic Amide Derivatives at Room Temperature

28 March 2025, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Herein, a mild and efficient cobalt-catalyzed electrochemical method for the C–H acyloxylation of aromatic and vinylic amides is reported. The 8-aminoquinoline directing group facilitates selective (ortho-)acyloxylation under electrochemical conditions at room temperature without the need for additional redox reagents. This sustainable protocol exhibits broad functional group tolerance and provides access to a wide range of acyloxylated amide derivatives using readily available carboxylic acids. The electrochemical approach avoids stoichiometric oxidants, generating only hydrogen as the byproduct, and thus offers a valuable alternative to traditional C–H functionalization strategies.

Keywords

Electrochemistry
Sustainable Synthesis
C-H Acyloxylation
Cobalt
8-Aminoquinoline

Supplementary materials

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Description
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Supporting Information
Description
Contains information about experimental procedures, and reaction set-ups, as well as NMR characterization data.
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