Temporal and Spatial Control Over Fiber Alignment Within Hyaluronic Acid Hydrogels Using Magnetic Fields

26 March 2025, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Wound healing is tightly regulated in both space and time. To mimic this behavior, we designed magnetically-responsive, fiber-hydrogel composites. When covalently crosslinked hydrogels were combined with layer-by-layer stacking, we demonstrated precise spatial control over fiber orientation. For temporal control, we used non-covalently crosslinked hydrogels to enable in situ fiber alignment.

Keywords

Magnetically-responsive
hydrogels
composites
spatial control
temporal control
fibers

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