Syntheses of Natural and Non-Natural β-Amino Acids Using Racemic and Enantioselective Sulfamate-Tethered Aza- Michael Cyclization Reactions

We detail the preparation of a library of ten β-amino acids (7 racemic and 3 scalemic), highlighting our laboratory’s racemic and enantioselective sulfamate-tethered aza-Michael cyclization reactions. All ten syntheses proceed from oxathiazinane heterocycles furnished by reactions invented in our laboratory. This work raises the prominence of sulfamate-tethered aza-Michael technology and advocates for the more general use of sulfamates in olefin functionalization processes.