Abstract
Phenol overoxidation has severely hindered the advancement and synthetic utility of oxidative phenol coupling for over two decades, preventing the development of general catalytic methods. Electron-deficient phenols resist selective cou-pling due to their high oxidation potential, while monosubstituted phenols undergo uncontrolled overoxidation, making their selective transformation highly challenging. We present a strategy that harnesses in-situ bisphenol-boron complex-ation to suppress overoxidation, unlocking the selective catalytic oxidative coupling of both electron-deficient and mono-substituted phenols. This method is broadly applicable to both heterogeneous and homogeneous photocatalytic systems, each operating via distinct mechanisms. By overcoming a fundamental barrier in oxidative phenol coupling, this work not only redefines the scope of catalytic oxidative transformations but also paves the way for new advances in oxidative couplings with implications in pharmaceuticals and materials science.
Supplementary materials
Title
Borate-Assisted Selective Photocatalytic Oxidative Dimerization of Electronically Diverse Phenols
Description
Supporting information for "Borate-Assisted Selective Photocatalytic Oxidative Dimerization of Electronically Diverse Phenols".
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