The Synthesis of Cyclopropyl-Fused Tetrahydrofurans from Vinyl-cyclopropanes

17 March 2025, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The rapid synthesis of oxabicyclo[3.1.0]hexanols from various vinyl cyclopropanes is described. Several carbonyl functionalities were incorporated, as were a range of electronically and sterically diverse aromatic and aliphatic substituents. This structurally unu-sual building block was then showcased through the rapid synthesis of a series of structurally complex polycyclic compounds.

Keywords

Oxabicyclo[3.1.0]hexanols
Iodocyclization
Heterocyclic compounds
Cyclopropane chemistry

Supplementary materials

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Description
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Experimental supporting information
Description
Detailed synthetic procedures for access to all intermediates including NMR spectra for all novel compounds
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