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Abstract
ABSTRACT: We report an enantio- and diastereoselective Michael spirocyclization reaction of tetrasubstituted palladium enolates. This allows for the formation of adjacent all-carbon quaternary and tertiary stereocenters in good yield, dr, and ee. Various subsequent cyclization reactions enable access to a diverse range of tricyclic scaffolds. The mechanism of this trans-formation is evaluated via quantum mechanics calculations to elucidate the origins of stereoselectivity and the mechanism of catalyst turnover.
Supplementary materials
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Supporting Information
Description
experimental procedures and spectra
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X-Ray Files
Description
cif files of X-ray structures
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QM_Energies
Description
Computational: Quantum mechanical energies
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computed structures
Description
computed structures
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