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An Approach to Alkyl Azetidines for Medicinal Chemistry

25 February 2025, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Alkyl azetidines have been prepared by photochemical modifications of azetidine-2-carboxylic acids in batch and in flow. The reaction has been realized in mg-, g-, and even multigram quantities. The obtained azetidines are valuable building blocks for drug discovery.

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Version History

Feb 25, 2025 Version 1

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The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2025-qmdhg
D O I: 10.26434/chemrxiv-2025-qmdhg [opens in a new tab]

Author’s competing interest statement

Athors of this work are employees of Enamine and Pfizer.

Ethics

The author(s) declare that they have sought and gained approval from the relevant ethics committee/IRB for this research and its publication.

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