Synthesis of α,α-Difluoro-β-amino Amides using Aldimines and Bromodifluoroacetamides via Zinc-Promoted Reformatsky Reaction

α,α-Difluoro-β-amino amides are one of the attractive building blocks of biologically active compounds such as fluorinated pharmaceutical mimics and oligopeptides. Herein, we describe zinc-promoted Reformatosky reaction of aldimines using bromodifluoroacetamides provides a directly synthetic approach to α,α-difluoro-β-amino amides. This method gave various N-PMP protected α,α-difluoro-β-amino-β-aryl amides in 64–95% yields.