![Author ORCID: We display the ORCID iD icon alongside authors names on our website to acknowledge that the ORCiD has been authenticated when entered by the user. To view the users ORCiD record click the icon. [opens in a new tab]](https://chemrxiv.org/engage/assets/public/chemrxiv/images/logos/orcid.png)
Abstract
This study introduces novel thiol-sensitive liposomes using pyridazinedione-based synthetic phospholipids. These formulations are designed to achieve an optimal balance between stability and responsiveness under tumour-specific conditions, enabling triggered release. Characterisation reveals the importance of phospholipid type and chain length in optimising reactivity and stability. This platform shows promise for advancing cancer nanomedicine through precise, stimulus-responsive delivery systems.
Supplementary materials
Title
Novel synthetic phospholipids for the preparation of thiol-responsive liposomes
Description
Synthetic procedures for the preparation of all products, liposome formulation, fluorescence spectra, characterisation data, copies of 1H NMR and 13C NMR spectra for all the synthesized compounds.
Actions
