A REVIEW ON APPLICATIONS AND PREPARATION METHODS USED FOR THE DEVELOPMENT OF CURCUMIN NANOPARTICLE

The design and development of Curcumin nanoparticles has attracted and established torrential research in nano formulation matrix. By appearance Curcumin is an orange crystalline powder which is derived or obtained from the herbs Curcumin Longa Linn (Zingiberaceae). The Curcumin is natural hydrophobic polyphenol compound which has proven to be a quintessential medicine in ancient China and many parts of Southeast and central Asia. Curcumin as a substance is vitally used in medicine and some food industry as it supplies many biological and pharmacological activities such as antioxidant, anti-inflammatory, anti-microbial, anti-illness and diseases but clinal application of this compound is limited due to its bioavailability, poor water solubility, fast metabolism and susceptibility to degradation in the alkaline medium. The most important methods to enhance the poor biopharmaceutical properties of Curcumin is to enhance aqueous solubility and bioavailability by using nanotechnology and nanoparticles having a small size in nanometer range. This review provides an overview of application and preparation of Curcumin nanoparticles including the advantages and limitations.