RDRP of β-alanine for DOX-release as a Proof-of-Concept dye Encapsulation for Nanoparticle Synthesis.

pH-responsive amphiphilic poly(β alanine acrylamide)-block-poly( methyl methacrylate)-umbelliferon (PBAAM-b-PMMA) diblock copolymer biohybrids, based of hydrophilic PBAAM and hydrophobic PMAA segments, is developed via direct switching from Zn-mediated RDRP. EbiB was used to mediate RDRP of a β-alanine derived monomer, PBAAM, yielding a series of (PBAAM-b-PMMA)-The copolymer's stimuli response has been assessed against pH changes. The translation of this structure into a synthetic polymer was the aim of this investigation. This copolymer is capable of dye encapsulation as a proof of concept of Beta-alanine Nanoparticle (NPs) DOX-release