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Abstract
Trimethoxyphenylsilane catalysed amidation protocol demonstrated for amide synthesis in refluxing toluene. The desired amide product is obtained by a simple acid-base workup protocol with moderate to good yield up to 67%. Without need of any dehydrating agent under simple azeotropic reflux condition make this protocol attractive for amidation reaction. Compatibility of trimethoxyphenyl silane with challenging aromatic acid and amine demonstrates its catalytic potency for amidation reactions.
Supplementary materials
Title
Supporting Information File
Description
Experimental procedures, characterisation data, NMR spectra,
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