In-Situ Generated Sulfinates from -Thioamide Sulfone as Nucleophilic Coupling Partners in Copper-Catalyzed Ring-Opening/Sulfonylation of Cyclopropenes: Access to Alkyl Aryl Sulfones

Sulfone plays an important role in our daily lives; developing methodologies to construct it has attracted considerable attention. Here, we introduce a protocol for the preparation of alkyl aryl sulfones under mild conditions. This protocol employs -thioamide sulfone as a novel sulfone motif donor. It forms sulfinates in situ under basic conditions, which then undergoes cross-coupling with the intermediates that were generated from ligand-free copper-catalyzed cyclopropenes (CPEs) ring-opening.