Reversible Aminolysis: A New Concept for Postpolymerization Modification

Despite the powerful synthetic benefits of aminolysis postpolymerization modifications (PPMs), conventional aminolysis PPMs suffer from irreversibility owing to the difficulties in cleaving amide bonds formed from activated esters and amines. This occurs because conventional activated esters are chemically activated by enhancing the leaving group ability of alcohol residues. In this study, we propose a new aminolysis PPM system that enables reversible reactions by regenerating activated esters.