Rh-Catalyzed Enantioselective Hydrosilylation of Unactivated Alkenes

29 October 2024, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Here, we report a highly efficient rhodium-catalyzed enantioselective hydrosilylation of unactivated alkenes, achieving excellent regioselectivity and high enantioselectivity. The use of a commercially available chiral ferrocene-based phosphine-oxazoline ligand was crucial in achieving excellent chiral induction and high reactivity with undirected unactiviated alkenes, delivering Si-stereogenic monohydrosilanes in high yields and excellent enantioselectivities. This protocol represents a robust, scalable method for the enantioselective synthesis of Si-stereogenic monohydrosilanes, featuring a low catalyst loading, a broad substrate scope and exceptional functional group and heterocycle tolerance. Moreover, the late-stage functionalization of complex motifs opens a new avenue for incorporating chiral silicon motifs into pharmaceuticals and bioactive compounds.

Keywords

rhodium
Alkene
hydrosilylation
Si-Stereogenic Silane
Enantioselective

Supplementary materials

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Title
SI Rh-AlkeneHydrosilylation-Wang
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Supporting Information
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