Cambridge Open Engage home
What is Cambridge Open Engage?
How to Submit
Browse
About
News [opens in a new tab]

Analysis of adenosine phosphonucleotides in blood by nh-PHIP

16 October 2024, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The sensitivity of conventional NMR is limited to metabolites at mid-micromolar concentrations, however diagnostically relevant metabolites are often found at lower concentrations. nh-PHIP has shown promise for analyzing complex biological samples like urine, but adapting it to blood presents additional challenges due to its complex matrix. Herein we successfully demonstrate the use of nh-PHIP for detecting adenine phosphonucleotides in blood.

Keywords

nhPHIP
parahydrogen
blood
adenosine phosphonucleotides

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Version History

Oct 16, 2024 Version 1

Metrics

157
75
0
Views
Downloads
Citations

License

CC logo
CC
BY logo
BY
The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2024-kr41w
D O I: 10.26434/chemrxiv-2024-kr41w [opens in a new tab]

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) declare that they have sought and gained approval from the relevant ethics committee/IRB for this research and its publication.

Share