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Abstract
Pectin is a bioactive polysaccharide widely investigated for its therapeutic properties as well as in tissue engineering and regenerative medicine for its gelling behavior, wound healing ability and high biocompatibility. First isolated in 2019 via hydrodynamic cavitation carried out in water only of the by-product of the industrial process of manufacturing orange juice, IntegroPectin is a new pectin-based phytocomplex rich in citrus flavonoids and terpenes whose low-methoxyl pectin backbone is enriched in RG-I rhamnogalacturonan regions. Antioxidant, anti-inflammatory, cardioprotective, neuroprotective, mitoprotective, antimicrobial and anticancer properties comprise the multitarget biological activity demonstrated so far investigating lemon, grapefruit, and mandarin IntegroPectin in both in vitro and in vivo studies. Research achievements in the first five years following its discovery highlight the large potential of citrus IntegroPectin as therapeutic and preventive agent. A critical perspective towards production and practical uptake of this new phytocomplex for the treatment and prevention of numerous ailments concludes the review.
