Easily Accessible and Solution-Stable Ni(0) Precatalysts for High-Throughput Experimentation

07 October 2024, Version 2
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We report the synthesis, characterization, and catalytic applications of N,N’-diaryl diazabutadiene (DAB) Ni(0) complexes stabilized by alkene ligands. These complexes are soluble and stable in several organic solvents, making them ideal candidates for in situ catalyst formation during high-throughput experimentation (HTE). We used HTE to evaluate these Ni(0) precatalysts in a variety of Suzuki and C–N coupling reactions, and they were found to have equal or better performance than the still ‘industry-standard’ Ni(0) source, Ni(COD)2.

Keywords

nickel precatalyst
homogenous catalysis
cross-coupling
high-throughput experimentation
organic synthesis

Supplementary materials

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Supporting Information
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Detailed experimental procedures, data tables, and characterization spectra.
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