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Abstract
An acid-promoted dearomative rearrangement of O-arylhydroxylamines affords 2-aminocyclohexadien-1-ones, which can in turn be reductively quenched for the synthesis of trans-aminoalcohols on a cyclohexadiene core. This method serves as an efficient entry to the pharmaceutically relevant 1-arylcyclohexylamine scaffold in two steps (one purification) from commercially available or readily prepared 2-arylphenols.
Supplementary materials
Title
Supporting Information
Description
Experimental details, materials, methods, characterization data, NMR spectra for all compounds, and information on X-ray diffraction experiments
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